Freezing in Parkinson's disease: a spatiotemporal motor disorder beyond gait.
Identifieur interne : 000D86 ( Main/Exploration ); précédent : 000D85; suivant : 000D87Freezing in Parkinson's disease: a spatiotemporal motor disorder beyond gait.
Auteurs : Sarah Vercruysse [Belgique] ; Joke Spildooren ; Elke Heremans ; Jochen Vandenbossche ; Oron Levin ; Nicole Wenderoth ; Stephan P. Swinnen ; Luc Janssens ; Wim Vandenberghe ; Alice NieuwboerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Biomechanical Phenomena, Female, Freezing Reaction, Cataleptic (physiology), Gait Disorders, Neurologic (diagnosis), Gait Disorders, Neurologic (etiology), Humans, Male, Mental Status Schedule, Middle Aged, Movement (physiology), Parkinson Disease (complications), Periodicity, Questionnaires, Severity of Illness Index, Spectrum Analysis, Upper Extremity (physiopathology).
- MESH :
- complications : Parkinson Disease.
- diagnosis : Gait Disorders, Neurologic.
- etiology : Gait Disorders, Neurologic.
- physiology : Freezing Reaction, Cataleptic, Movement.
- physiopathology : Upper Extremity.
- Aged, Analysis of Variance, Biomechanical Phenomena, Female, Humans, Male, Mental Status Schedule, Middle Aged, Periodicity, Questionnaires, Severity of Illness Index, Spectrum Analysis.
Abstract
Freezing of gait (FOG) is an incapacitating problem in Parkinson's disease that is difficult to manage therapeutically. We tested the hypothesis that impaired rhythm and amplitude control is a common mechanism of freezing which is also present during other rhythmic tasks. Therefore, we compared the occurrence and spatiotemporal profiles of freezing episodes during upper limb motion, lower limb motion, and FOG. Eleven freezers, 12 non-freezers, and 11 controls performed a rhythmic bilateral finger movement task. The triggering effect of movement speed, amplitude, and coordination pattern was evaluated. Regression slopes and spectral analysis addressed the spatial and temporal kinematic changes inherent to freezing episodes. The FOG Questionnaire score significantly predicted severity of upper limb freezing, present in 9 freezers, and of foot freezing, present in 8 freezers. Similar to gait, small-amplitude movements tended to trigger upper limb freezing, which was preceded by hastened movement and a strong amplitude breakdown. Upper limb freezing power spectra were broadband, including increased energy in the "freeze band" (3-8 Hz). Contrary to FOG, unilateral upper limb freezing was common and occurred mainly on the disease-dominant side. The findings emphasize that a core motor problem underlies freezing which can affect various movement effectors. This deficit may originate on the disease-dominant body side and interfere with amplitude and timing regulation during repetitive limb movements. These results may shift current thinking on the origins of freezing as being not exclusively a gait failure.
DOI: 10.1002/mds.24015
PubMed: 22020744
Affiliations:
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Swinnen</name></author><author><name sortKey="Janssens, Luc" sort="Janssens, Luc" uniqKey="Janssens L" first="Luc" last="Janssens">Luc Janssens</name></author><author><name sortKey="Vandenberghe, Wim" sort="Vandenberghe, Wim" uniqKey="Vandenberghe W" first="Wim" last="Vandenberghe">Wim Vandenberghe</name></author><author><name sortKey="Nieuwboer, Alice" sort="Nieuwboer, Alice" uniqKey="Nieuwboer A" first="Alice" last="Nieuwboer">Alice Nieuwboer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.24015</idno><idno type="RBID">pubmed:22020744</idno><idno type="pmid">22020744</idno><idno type="wicri:Area/PubMed/Corpus">000F96</idno><idno type="wicri:Area/PubMed/Curation">000F96</idno><idno type="wicri:Area/PubMed/Checkpoint">000E21</idno><idno type="wicri:Area/Ncbi/Merge">003434</idno><idno type="wicri:Area/Ncbi/Curation">003434</idno><idno type="wicri:Area/Ncbi/Checkpoint">003434</idno><idno type="wicri:Area/Main/Merge">000E13</idno><idno type="wicri:Area/Main/Curation">000D86</idno><idno type="wicri:Area/Main/Exploration">000D86</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Freezing in Parkinson's disease: a spatiotemporal motor disorder beyond gait.</title><author><name sortKey="Vercruysse, Sarah" sort="Vercruysse, Sarah" uniqKey="Vercruysse S" first="Sarah" last="Vercruysse">Sarah Vercruysse</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium. sarah.vercruysse@faber.kuleuven.be</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Spildooren, Joke" sort="Spildooren, Joke" uniqKey="Spildooren J" first="Joke" last="Spildooren">Joke Spildooren</name></author><author><name sortKey="Heremans, Elke" sort="Heremans, Elke" uniqKey="Heremans E" first="Elke" last="Heremans">Elke Heremans</name></author><author><name sortKey="Vandenbossche, Jochen" sort="Vandenbossche, Jochen" uniqKey="Vandenbossche J" first="Jochen" last="Vandenbossche">Jochen Vandenbossche</name></author><author><name sortKey="Levin, Oron" sort="Levin, Oron" uniqKey="Levin O" first="Oron" last="Levin">Oron Levin</name></author><author><name sortKey="Wenderoth, Nicole" sort="Wenderoth, Nicole" uniqKey="Wenderoth N" first="Nicole" last="Wenderoth">Nicole Wenderoth</name></author><author><name sortKey="Swinnen, Stephan P" sort="Swinnen, Stephan P" uniqKey="Swinnen S" first="Stephan P" last="Swinnen">Stephan P. Swinnen</name></author><author><name sortKey="Janssens, Luc" sort="Janssens, Luc" uniqKey="Janssens L" first="Luc" last="Janssens">Luc Janssens</name></author><author><name sortKey="Vandenberghe, Wim" sort="Vandenberghe, Wim" uniqKey="Vandenberghe W" first="Wim" last="Vandenberghe">Wim Vandenberghe</name></author><author><name sortKey="Nieuwboer, Alice" sort="Nieuwboer, Alice" uniqKey="Nieuwboer A" first="Alice" last="Nieuwboer">Alice Nieuwboer</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Biomechanical Phenomena</term><term>Female</term><term>Freezing Reaction, Cataleptic (physiology)</term><term>Gait Disorders, Neurologic (diagnosis)</term><term>Gait Disorders, Neurologic (etiology)</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Parkinson Disease (complications)</term><term>Periodicity</term><term>Questionnaires</term><term>Severity of Illness Index</term><term>Spectrum Analysis</term><term>Upper Extremity (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Freezing Reaction, Cataleptic</term><term>Movement</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Upper Extremity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Biomechanical Phenomena</term><term>Female</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Periodicity</term><term>Questionnaires</term><term>Severity of Illness Index</term><term>Spectrum Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Freezing of gait (FOG) is an incapacitating problem in Parkinson's disease that is difficult to manage therapeutically. We tested the hypothesis that impaired rhythm and amplitude control is a common mechanism of freezing which is also present during other rhythmic tasks. Therefore, we compared the occurrence and spatiotemporal profiles of freezing episodes during upper limb motion, lower limb motion, and FOG. Eleven freezers, 12 non-freezers, and 11 controls performed a rhythmic bilateral finger movement task. The triggering effect of movement speed, amplitude, and coordination pattern was evaluated. Regression slopes and spectral analysis addressed the spatial and temporal kinematic changes inherent to freezing episodes. The FOG Questionnaire score significantly predicted severity of upper limb freezing, present in 9 freezers, and of foot freezing, present in 8 freezers. Similar to gait, small-amplitude movements tended to trigger upper limb freezing, which was preceded by hastened movement and a strong amplitude breakdown. Upper limb freezing power spectra were broadband, including increased energy in the "freeze band" (3-8 Hz). Contrary to FOG, unilateral upper limb freezing was common and occurred mainly on the disease-dominant side. The findings emphasize that a core motor problem underlies freezing which can affect various movement effectors. This deficit may originate on the disease-dominant body side and interfere with amplitude and timing regulation during repetitive limb movements. These results may shift current thinking on the origins of freezing as being not exclusively a gait failure.</div></front></TEI><affiliations><list><country><li>Belgique</li></country></list><tree><noCountry><name sortKey="Heremans, Elke" sort="Heremans, Elke" uniqKey="Heremans E" first="Elke" last="Heremans">Elke Heremans</name><name sortKey="Janssens, Luc" sort="Janssens, Luc" uniqKey="Janssens L" first="Luc" last="Janssens">Luc Janssens</name><name sortKey="Levin, Oron" sort="Levin, Oron" uniqKey="Levin O" first="Oron" last="Levin">Oron Levin</name><name sortKey="Nieuwboer, Alice" sort="Nieuwboer, Alice" uniqKey="Nieuwboer A" first="Alice" last="Nieuwboer">Alice Nieuwboer</name><name sortKey="Spildooren, Joke" sort="Spildooren, Joke" uniqKey="Spildooren J" first="Joke" last="Spildooren">Joke Spildooren</name><name sortKey="Swinnen, Stephan P" sort="Swinnen, Stephan P" uniqKey="Swinnen S" first="Stephan P" last="Swinnen">Stephan P. Swinnen</name><name sortKey="Vandenberghe, Wim" sort="Vandenberghe, Wim" uniqKey="Vandenberghe W" first="Wim" last="Vandenberghe">Wim Vandenberghe</name><name sortKey="Vandenbossche, Jochen" sort="Vandenbossche, Jochen" uniqKey="Vandenbossche J" first="Jochen" last="Vandenbossche">Jochen Vandenbossche</name><name sortKey="Wenderoth, Nicole" sort="Wenderoth, Nicole" uniqKey="Wenderoth N" first="Nicole" last="Wenderoth">Nicole Wenderoth</name></noCountry><country name="Belgique"><noRegion><name sortKey="Vercruysse, Sarah" sort="Vercruysse, Sarah" uniqKey="Vercruysse S" first="Sarah" last="Vercruysse">Sarah Vercruysse</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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